This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2k1a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2k1a.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2k1a.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2k1a| PDB=2k1a | SCENE= }}
{{STRUCTURE_2k1a| PDB=2k1a | SCENE= }}
-
'''Bicelle-embedded integrin alpha(IIB) transmembrane segment'''
+
===Bicelle-embedded integrin alpha(IIB) transmembrane segment===
-
==Overview==
+
<!--
-
Integrin cell-adhesion receptors transduce signals bidirectionally across the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit. While the beta3 transmembrane segment consists of a linear 29-residue alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-helix (Ile-966 -Lys-989) followed by a backbone reversal that packs Phe-992-Phe-993 against the transmembrane helix. The length of the alphaIIb transmembrane helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering beta3 subunit. Sequence alignment shows Gly-991-Phe-993 to be fully conserved among all 18 human integrin alpha subunits, suggesting that their unusual structural motif is prototypical for integrin alpha subunits. The alphaIIb transmembrane structure demonstrates a level of complexity within the membrane that is beyond simple transmembrane helices and forms the structural basis for assessing the extent of structural and topological rearrangements upon alphaIIb-beta3 association, i.e. integrin transmembrane signaling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18417472}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18417472 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18417472}}
==About this Structure==
==About this Structure==
-
2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA].
+
2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA].
==Reference==
==Reference==
Line 36: Line 40:
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Single-pass transmembrane segment]]
[[Category: Single-pass transmembrane segment]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:16:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:27:21 2008''

Revision as of 14:27, 27 July 2008

Image:2k1a.png

Template:STRUCTURE 2k1a

Bicelle-embedded integrin alpha(IIB) transmembrane segment

Template:ABSTRACT PUBMED 18417472

About this Structure

2K1A is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the Integrin {alpha}IIb Transmembrane Segment., Lau TL, Dua V, Ulmer TS, J Biol Chem. 2008 Jun 6;283(23):16162-8. Epub 2008 Apr 16. PMID:18417472

Page seeded by OCA on Sun Jul 27 17:27:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2k1a"
Personal tools