2iw3

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{{STRUCTURE_2iw3| PDB=2iw3 | SCENE= }}
{{STRUCTURE_2iw3| PDB=2iw3 | SCENE= }}
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'''ELONGATION FACTOR 3 IN COMPLEX WITH ADP'''
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===ELONGATION FACTOR 3 IN COMPLEX WITH ADP===
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==Overview==
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Elongation factor eEF3 is an ATPase that, in addition to the two canonical factors eEF1A and eEF2, serves an essential function in the translation cycle of fungi. eEF3 is required for the binding of the aminoacyl-tRNA-eEF1A-GTP ternary complex to the ribosomal A-site and has been suggested to facilitate the clearance of deacyl-tRNA from the E-site. Here we present the crystal structure of Saccharomyces cerevisiae eEF3, showing that it consists of an amino-terminal HEAT repeat domain, followed by a four-helix bundle and two ABC-type ATPase domains, with a chromodomain inserted in ABC2. Moreover, we present the cryo-electron microscopy structure of the ATP-bound form of eEF3 in complex with the post-translocational-state 80S ribosome from yeast. eEF3 uses an entirely new factor binding site near the ribosomal E-site, with the chromodomain likely to stabilize the ribosomal L1 stalk in an open conformation, thus allowing tRNA release.
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{{ABSTRACT_PUBMED_16929303}}
==About this Structure==
==About this Structure==
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[[Category: Rrna-binding]]
[[Category: Rrna-binding]]
[[Category: Translation]]
[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:57:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:28:34 2008''

Revision as of 14:28, 27 July 2008

Image:2iw3.png

Template:STRUCTURE 2iw3

ELONGATION FACTOR 3 IN COMPLEX WITH ADP

Template:ABSTRACT PUBMED 16929303

About this Structure

2IW3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of eEF3 and the mechanism of transfer RNA release from the E-site., Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R, Nature. 2006 Oct 12;443(7112):663-8. Epub 2006 Aug 23. PMID:16929303

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