1on2

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{{STRUCTURE_1on2| PDB=1on2 | SCENE= }}
{{STRUCTURE_1on2| PDB=1on2 | SCENE= }}
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'''Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese'''
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===Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese===
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==Overview==
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The Bacillus subtilis manganese transport regulator, MntR, binds Mn2+ as an effector and is a repressor of transporters that import manganese. A member of the diphtheria toxin repressor (DtxR) family of metalloregulatory proteins, MntR exhibits selectivity for Mn2+ over Fe2+. Replacement of a metal-binding residue, Asp8, with methionine (D8M) relaxes this specificity. We report here the X-ray crystal structures of wild-type MntR and the D8M mutant bound to manganese with 1.75 A and 1.61 A resolution, respectively. The 142-residue MntR homodimer has substantial structural similarity to the 226-residue DtxR but lacks the C-terminal SH3-like domain of DtxR. The metal-binding pockets of MntR and DtxR are substantially different. The cation-to-cation distance between the two manganese ions bound by MntR is 3.3 A, whereas that between the metal ions bound by DtxR is 9 A. D8M binds only a single Mn2+ per monomer, owing to alteration of the metal-binding site. The sole retained metal site adopts pseudo-hexacoordinate geometry rather than the pseudo-heptacoordinate geometry of the MntR metal sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 12847518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12847518}}
==About this Structure==
==About this Structure==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Metalloregulatory protein]]
[[Category: Metalloregulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:34:12 2008''

Revision as of 14:34, 27 July 2008

Image:1on2.png

Template:STRUCTURE 1on2

Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese

Template:ABSTRACT PUBMED 12847518

About this Structure

1ON2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of the manganese-bound manganese transport regulator of Bacillus subtilis., Glasfeld A, Guedon E, Helmann JD, Brennan RG, Nat Struct Biol. 2003 Aug;10(8):652-7. PMID:12847518

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