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| - | [[Image:1w89.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1w89.png|left|200px]] |
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| | {{STRUCTURE_1w89| PDB=1w89 | SCENE= }} | | {{STRUCTURE_1w89| PDB=1w89 | SCENE= }} |
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| - | '''STRUCTURE OF THE REDUCED FORM OF HUMAN THIOREDOXIN 2'''
| + | ===STRUCTURE OF THE REDUCED FORM OF HUMAN THIOREDOXIN 2=== |
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| - | ==Overview==
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| - | Mammalian thioredoxin 2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions. In mammals, thioredoxin 2 is encoded by a nuclear gene and is targeted to mitochondria by a N-terminal mitochondrial presequence. Recently, mitochondrial thioredoxin 2 was shown to interact with components of the mitochondrial respiratory chain and to play a role in the control of mitochondrial membrane potential, regulating mitochondrial apoptosis signaling pathway. Here we report the first crystal structures of a mammalian mitochondrial thioredoxin 2. Crystal forms of reduced and oxidized human thioredoxin 2 are described at 2.0 and 1.8 A resolution. Though the folding is rather similar to that of human cytosolic/nuclear thioredoxin 1, important differences are observed during the transition between the oxidized and the reduced states of human thioredoxin 2, compared with human thioredoxin 1. In spite of the absence of the Cys residue implicated in dimer formation in human thioredoxin 1, dimerization still occurs in the crystal structure of human thioredoxin 2, mainly mediated by hydrophobic contacts, and the dimers are associated to form two-dimensional polymers. Interestingly, the structure of human thioredoxin 2 reveals possible interaction domains with human peroxiredoxin 5, a substrate protein of human thioredoxin 2 in mitochondria.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_16195549}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 16195549 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_16195549}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Mitochondrion]] | | [[Category: Mitochondrion]] |
| | [[Category: Thioredoxin]] | | [[Category: Thioredoxin]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:17:35 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:34:39 2008'' |
Revision as of 14:34, 27 July 2008
Template:STRUCTURE 1w89
STRUCTURE OF THE REDUCED FORM OF HUMAN THIOREDOXIN 2
Template:ABSTRACT PUBMED 16195549
About this Structure
1W89 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:16195549
Page seeded by OCA on Sun Jul 27 17:34:39 2008
