1n9e

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{{STRUCTURE_1n9e| PDB=1n9e | SCENE= }}
{{STRUCTURE_1n9e| PDB=1n9e | SCENE= }}
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'''CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO'''
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===CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO===
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==Overview==
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Pichia pastoris lysyl oxidase (PPLO) is unique among the structurally characterized copper amine oxidases in being able to oxidize the side chain of lysine residues in polypeptides. Remarkably, the yeast PPLO is nearly as effective in oxidizing a mammalian tropoelastin substrate as is a true mammalian lysyl oxidase isolated from bovine aorta. Thus, PPLO is functionally related to the copper-containing lysyl oxidases despite the lack of any significant sequence similarity with these enzymes. The structure of PPLO has been determined at 1.65 A resolution. PPLO is a homodimer in which each subunit contains a Type II copper atom and a topaquinone cofactor (TPQ) formed by the posttranslational modification of a tyrosine residue. While PPLO has tertiary and quaternary topologies similar to those found in other quinone-containing copper amine oxidases, its active site is substantially more exposed and accessible. The structural elements that are responsible for the accessibility of the active site are identified and discussed.
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{{ABSTRACT_PUBMED_14690425}}
==About this Structure==
==About this Structure==
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[[Category: Topaquinone enzyme]]
[[Category: Topaquinone enzyme]]
[[Category: Tpq]]
[[Category: Tpq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:35:10 2008''

Revision as of 14:35, 27 July 2008

Image:1n9e.png

Template:STRUCTURE 1n9e

CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO

Template:ABSTRACT PUBMED 14690425

About this Structure

1N9E is a Single protein structure of sequence from Pichia pastoris. Full crystallographic information is available from OCA.

Reference

The crystal structure of Pichia pastoris lysyl oxidase., Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM, Biochemistry. 2003 Dec 30;42(51):15148-57. PMID:14690425

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