2pi0

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{{STRUCTURE_2pi0| PDB=2pi0 | SCENE= }}
{{STRUCTURE_2pi0| PDB=2pi0 | SCENE= }}
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'''Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer'''
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===Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer===
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==Overview==
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Interferon regulatory factor 3 (IRF-3) is a key transcription factor in the assembly of the mammalian interferon-beta (IFN-beta) enhanceosome. We present here the structure of IRF-3 DNA binding domain in complex with the complete PRDIII-I regulatory element of the human IFN-beta enhancer. We show that four IRF-3 molecules bind in tandem to, variably spaced, consensus and nonconsensus IRF sites on the composite element. The ability of IRF-3 to bind these variable sites derives in part from two nonconserved arginines (Arg78 and Arg86) that partake in alternate protein-DNA contacts. We also show that the protein-DNA contacts are highly overlapped and that all four IRF sites are required for gene activation in vivo. In addition, we show that changing the nonconsensus IRF sites to consensus sites creates a more efficient enhancer in vivo. Together, the structure and accompanying biological data provide insights into the assembly of the IFN-beta enhanceosome in mammals.
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(as it appears on PubMed at http://www.pubmed.gov), where 17560375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17560375}}
==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription activator/dna complex]]
[[Category: Transcription activator/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:08:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:35:46 2008''

Revision as of 14:35, 27 July 2008

Image:2pi0.png

Template:STRUCTURE 2pi0

Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer

Template:ABSTRACT PUBMED 17560375

About this Structure

2PI0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer., Escalante CR, Nistal-Villan E, Shen L, Garcia-Sastre A, Aggarwal AK, Mol Cell. 2007 Jun 8;26(5):703-16. PMID:17560375

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