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2oot

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[[Image:2oot.gif|left|200px]]
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{{STRUCTURE_2oot| PDB=2oot | SCENE= }}
{{STRUCTURE_2oot| PDB=2oot | SCENE= }}
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'''A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II'''
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===A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II===
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==Overview==
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Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 A. This work reports the structure of the protein refined to 1.65 A resolution, with crystallographic values of R = 0.207 and R(free) = 0.228. The new structure extends the resolution appreciably and the new model based on this data shows significant differences when compared with the previously published model.
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(as it appears on PubMed at http://www.pubmed.gov), where 17329803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17329803}}
==About this Structure==
==About this Structure==
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[[Category: Naaladase]]
[[Category: Naaladase]]
[[Category: Prostate-specific membrane antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:21:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:42:22 2008''

Revision as of 14:42, 27 July 2008

Image:2oot.png

Template:STRUCTURE 2oot

A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II

Template:ABSTRACT PUBMED 17329803

About this Structure

2OOT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A high-resolution structure of ligand-free human glutamate carboxypeptidase II., Barinka C, Starkova J, Konvalinka J, Lubkowski J, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):150-3. Epub 2007 Feb 13. PMID:17329803

Page seeded by OCA on Sun Jul 27 17:42:22 2008

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