3c45

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{{STRUCTURE_3c45| PDB=3c45 | SCENE= }}
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'''Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor'''
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===Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor===
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==Overview==
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The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin 33 was shown to possess a high propensity to form reactive metabolites, thus revealing a potential liability for this class of DPP-4 inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 18331795 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18331795}}
==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:52:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:44:58 2008''

Revision as of 14:45, 27 July 2008

Image:3c45.png

Template:STRUCTURE 3c45

Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor

Template:ABSTRACT PUBMED 18331795

About this Structure

3C45 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors., Edmondson SD, Wei L, Xu J, Shang J, Xu S, Pang J, Chaudhary A, Dean DC, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Scapin G, Wu JK, Beconi MG, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2008 Apr 1;18(7):2409-13. Epub 2008 Feb 26. PMID:18331795

Page seeded by OCA on Sun Jul 27 17:44:58 2008

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