1qxz

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[[Image:1qxz.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qxz| PDB=1qxz | SCENE= }}
{{STRUCTURE_1qxz| PDB=1qxz | SCENE= }}
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'''Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119'''
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===Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119===
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==Overview==
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High-resolution crystal structures of Staphylococcus aureus methionine aminopeptidase I in complex with various keto heterocycles and aminoketones were determined, and the intermolecular ligand interactions with the enzyme are reported. The compounds are effective inhibitors of the S. aureus enzyme because of the formation of an uncleavable tetrahedral intermediate upon binding. The electron densities unequivocally show the enzyme-catalyzed transition-state analogue mimicking that for amide bond hydrolysis of substrates.
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The line below this paragraph, {{ABSTRACT_PUBMED_14998322}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14998322 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14998322}}
==About this Structure==
==About this Structure==
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[[Category: Oefner, C.]]
[[Category: Oefner, C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:50:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:46:18 2008''

Revision as of 14:46, 27 July 2008

Image:1qxz.png

Template:STRUCTURE 1qxz

Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119

Template:ABSTRACT PUBMED 14998322

About this Structure

1QXZ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate., Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C, J Med Chem. 2004 Mar 11;47(6):1325-8. PMID:14998322

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