2nn2

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{{STRUCTURE_2nn2| PDB=2nn2 | SCENE= }}
{{STRUCTURE_2nn2| PDB=2nn2 | SCENE= }}
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'''Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator'''
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===Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator===
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==Overview==
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BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a protein-protein interaction motif that contains a dimerization interface, a possible oligomerization surface, and surfaces for interactions with other factors, including nuclear co-repressors and histone deacetylases. The BTB-ZF protein LRF (also known as ZBTB7, FBI-1, OCZF, and Pokemon) is a master regulator of oncogenesis, and represses the transcription of a variety of important genes, including the ARF, c-fos, and c-myc oncogenes and extracellular matrix genes. We determined the crystal structure of the BTB domain from human LRF to 2.1 A and observed the canonical BTB homodimer fold. However, novel features are apparent on the surface of the homodimer, including differences in the lateral groove and charged pocket regions. The residues that line the lateral groove have little similarity with the equivalent residues from the BCL6 BTB domain, and we show that the 17-residue BCL6 Binding Domain (BBD) from the SMRT co-repressor does not bind to the LRF BTB domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 17189472 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17189472}}
==About this Structure==
==About this Structure==
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[[Category: Transcription repressor]]
[[Category: Transcription repressor]]
[[Category: Zinc-finger protein]]
[[Category: Zinc-finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:39:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:48:46 2008''

Revision as of 14:48, 27 July 2008

Image:2nn2.png

Template:STRUCTURE 2nn2

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator

Template:ABSTRACT PUBMED 17189472

About this Structure

2NN2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator., Stogios PJ, Chen L, Prive GG, Protein Sci. 2007 Feb;16(2):336-42. Epub 2006 Dec 22. PMID:17189472

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