1r8o

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[[Image:1r8o.jpg|left|200px]]
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{{Seed}}
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[[Image:1r8o.png|left|200px]]
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{{STRUCTURE_1r8o| PDB=1r8o | SCENE= }}
{{STRUCTURE_1r8o| PDB=1r8o | SCENE= }}
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'''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds'''
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===Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds===
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==Overview==
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The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI is the first structure of a member of Kunitz (STI) family formed by two noncovalently bound polypeptide chains and only one disulfide bridge. A standard Kunitz-type inhibitor has a single polypeptide chain and two disulfide bridges. Structural features granting CTI high inhibitory activity are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_15134830}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15134830 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15134830}}
==About this Structure==
==About this Structure==
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[[Category: Copaifera langsdorffii]]
[[Category: Copaifera langsdorffii]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:13:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:48:53 2008''

Revision as of 14:49, 27 July 2008

Image:1r8o.png

Template:STRUCTURE 1r8o

Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds

Template:ABSTRACT PUBMED 15134830

About this Structure

1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830

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