1riw

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[[Image:1riw.gif|left|200px]]
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{{STRUCTURE_1riw| PDB=1riw | SCENE= }}
{{STRUCTURE_1riw| PDB=1riw | SCENE= }}
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'''Thrombin in complex with natural product inhibitor Oscillarin'''
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===Thrombin in complex with natural product inhibitor Oscillarin===
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==Overview==
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The first enantiocontrolled total synthesis of the marine natural product oscillarin is described. The proposed structure and absolute configuration of oscillarin is thus confirmed, and a previously assigned structure of a subunit was shown to be incorrect. The X-ray structure of an oscillarin-thrombin complex was resolved at 2.0 A resolution, which validated its potent inhibitory activity against the enzyme with an IC(50) = 28 nM. Methodology was developed for the synthesis of enantiopure octahydroindole-2-carboxylic acids with usable functionality at C-6. The method consists of the halocarbocyclization of N-acyloxyiminium ions containing an olefinic tether in the presence of tin tetrachloride or tin tetrabromide. This N-acyloxyiminium ion aza-Prins carbocyclization proved to be general for the construction of octahydroindole and perhydroquinoline 2-carboxylic acids. Mechanistic rationales are based on an antiperiplanar attack of the terminal alkene on the iminium ion, leading to an incipient secondary carbocation which is trapped by halide via an equatorial attack. X-ray crystal structures of products corroborate the expected stereochemistry.
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(as it appears on PubMed at http://www.pubmed.gov), where 15137772 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15137772}}
==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:33:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:49:29 2008''

Revision as of 14:49, 27 July 2008

Image:1riw.png

Template:STRUCTURE 1riw

Thrombin in complex with natural product inhibitor Oscillarin

Template:ABSTRACT PUBMED 15137772

About this Structure

1RIW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin., Hanessian S, Tremblay M, Petersen JF, J Am Chem Soc. 2004 May 19;126(19):6064-71. PMID:15137772

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