2ak2

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{{STRUCTURE_2ak2| PDB=2ak2 | SCENE= }}
{{STRUCTURE_2ak2| PDB=2ak2 | SCENE= }}
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'''ADENYLATE KINASE ISOENZYME-2'''
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===ADENYLATE KINASE ISOENZYME-2===
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==Overview==
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In vertebrates, there are different adenylate kinases in the compartments cytosol, mitochondrial intermembrane space, and mitochondrial matrix. Here, we report the spatial structure of the intermembrane species established in two crystal forms by X-ray diffraction analyses at 1.92 and 2.1 A resolution. In both structures, the enzyme is unligated, and thus in an "open" conformation. The enzyme was prepared from bovine liver, containing at least five variants arisen from posttranscriptional and posttranslational modifications. It could only be crystallized after removing some of these variants. A comparison with the known structures of the adenylate kinases from cytosol and mitochondrial matrix reveals structural differences that should play a role in protein targeting because none of these enzymes contains a cleavable signal peptide. A further comparison with adenylate kinases from Gram-positive bacteria showed that the structural Zn2+ ion of these species is replaced by a strictly conserved assembly of hydrogen bonded residues.
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{{ABSTRACT_PUBMED_8868479}}
==About this Structure==
==About this Structure==
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[[Category: Nucleoside monophosphate kinase]]
[[Category: Nucleoside monophosphate kinase]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:08:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:50:27 2008''

Revision as of 14:50, 27 July 2008

Image:2ak2.png

Template:STRUCTURE 2ak2

ADENYLATE KINASE ISOENZYME-2

Template:ABSTRACT PUBMED 8868479

About this Structure

2AK2 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The structure of bovine mitochondrial adenylate kinase: comparison with isoenzymes in other compartments., Schlauderer GJ, Schulz GE, Protein Sci. 1996 Mar;5(3):434-41. PMID:8868479

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