2e9x

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{{STRUCTURE_2e9x| PDB=2e9x | SCENE= }}
{{STRUCTURE_2e9x| PDB=2e9x | SCENE= }}
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'''The crystal structure of human GINS core complex'''
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===The crystal structure of human GINS core complex===
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==Overview==
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The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. We report the crystal structure of the human GINS complex. The heterotetrameric complex adopts a pseudo symmetrical layered structure comprising two heterodimers, creating four subunit-subunit interfaces. The subunit structures of the heterodimers consist of two alternating domains. The C-terminal domains of the Sld5 and Psf1 subunits are connected by linker regions to the core complex, and the C-terminal domain of Sld5 is important for core complex assembly. In contrast, the C-terminal domain of Psf1 does not contribute to the stability of the complex but is crucial for chromatin binding and replication activity. These data suggest that the core complex ensures a stable platform for the C-terminal domain of Psf1 to act as a key interaction interface for other proteins in the replication-initiation process.
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(as it appears on PubMed at http://www.pubmed.gov), where 17417653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17417653}}
==Disease==
==Disease==
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[[Category: Eukaryotic dna replication]]
[[Category: Eukaryotic dna replication]]
[[Category: Gins complex]]
[[Category: Gins complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:12:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:51:28 2008''

Revision as of 14:51, 27 July 2008

Image:2e9x.png

Template:STRUCTURE 2e9x

Contents

The crystal structure of human GINS core complex

Template:ABSTRACT PUBMED 17417653

Disease

Known disease associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260], Bare lymphocyte syndrome, type I, due to TAP2 deficiency OMIM:[170261], Wegener-like granulomatosis OMIM:[170261]

About this Structure

2E9X is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human GINS complex and its assembly and functional interface in replication initiation., Kamada K, Kubota Y, Arata T, Shindo Y, Hanaoka F, Nat Struct Mol Biol. 2007 May;14(5):388-96. Epub 2007 Apr 8. PMID:17417653

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