2d47

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{{STRUCTURE_2d47| PDB=2d47 | SCENE= }}
{{STRUCTURE_2d47| PDB=2d47 | SCENE= }}
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'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''
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===MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA===
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==Overview==
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We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.
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The line below this paragraph, {{ABSTRACT_PUBMED_1920437}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1920437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1920437}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:40:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:52:24 2008''

Revision as of 14:52, 27 July 2008

Image:2d47.png

Template:STRUCTURE 2d47

MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA

Template:ABSTRACT PUBMED 1920437

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:1920437

Page seeded by OCA on Sun Jul 27 17:52:24 2008

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