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1zub

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[[Image:1zub.gif|left|200px]]
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[[Image:1zub.png|left|200px]]
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{{STRUCTURE_1zub| PDB=1zub | SCENE= }}
{{STRUCTURE_1zub| PDB=1zub | SCENE= }}
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'''Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide'''
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===Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide===
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==Overview==
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PDZ domains are widespread protein modules that commonly recognize C-terminal sequences of target proteins and help to organize macromolecular signaling complexes. These sequences usually bind in an extended conformation to relatively shallow grooves formed between a beta-strand and an alpha-helix in the corresponding PDZ domains. Because of this binding mode, many PDZ domains recognize primarily the C-terminal and the antepenultimate side-chains of the target protein, which commonly conform to motifs that have been categorized into different classes. However, an increasing number of PDZ domains have been found to exhibit unusual specificities. These include the PDZ domain of RIMs, which are large multidomain proteins that regulate neurotransmitter release and help to organize presynaptic active zones. The RIM PDZ domain binds to the C-terminal sequence of ELKS with a unique specificity that involves each of the four ELKS C-terminal residues. To elucidate the structural basis for this specificity, we have determined the 3D structure in solution of an RIM/ELKS C-terminal peptide complex using NMR spectroscopy. The structure shows that the RIM PDZ domain contains an unusually deep and narrow peptide-binding groove with an exquisite shape complementarity to the four ELKS C-terminal residues in their bound conformation. This groove is formed, in part, by a set of side-chains that is conserved selectively in RIM PDZ domains and that hence determines, at least in part, their unique specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16095618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16095618}}
==About this Structure==
==About this Structure==
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1ZUB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUB OCA].
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1ZUB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUB OCA].
==Reference==
==Reference==
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[[Category: Pdz domain]]
[[Category: Pdz domain]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:05:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:54:51 2008''

Revision as of 14:54, 27 July 2008

Image:1zub.png

Template:STRUCTURE 1zub

Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide

Template:ABSTRACT PUBMED 16095618

About this Structure

1ZUB is a Protein complex structure of sequences from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide., Lu J, Li H, Wang Y, Sudhof TC, Rizo J, J Mol Biol. 2005 Sep 16;352(2):455-66. PMID:16095618

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