2flb

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{{STRUCTURE_2flb| PDB=2flb | SCENE= }}
{{STRUCTURE_2flb| PDB=2flb | SCENE= }}
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'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''
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===Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor===
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==Overview==
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Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
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The line below this paragraph, {{ABSTRACT_PUBMED_16487703}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16487703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16487703}}
==Disease==
==Disease==
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[[Category: Pyrazole-based inhibitor]]
[[Category: Pyrazole-based inhibitor]]
[[Category: Short hydrogen bond-mediated]]
[[Category: Short hydrogen bond-mediated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:01:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:55:22 2008''

Revision as of 14:55, 27 July 2008

Template:STRUCTURE 2flb

Contents

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

Template:ABSTRACT PUBMED 16487703

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2FLB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703

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