1zv2

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[[Image:1zv2.gif|left|200px]]
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{{Seed}}
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[[Image:1zv2.png|left|200px]]
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{{STRUCTURE_1zv2| PDB=1zv2 | SCENE= }}
{{STRUCTURE_1zv2| PDB=1zv2 | SCENE= }}
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'''Cu-containing nitrite reductase'''
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===Cu-containing nitrite reductase===
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==Overview==
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Nitrite reductase is an enzyme operating in the denitrification pathway which catalyses the conversion of nitrite (NO2(-)) to gaseous nitric oxide (NO). Here, crystal structures of the oxidized and reduced forms of the copper-containing nitrite reductase from Rhodobacter sphaeroides 2.4.3 are presented at 1.74 and 1.85 A resolution, respectively. Whereas the structure of the enzyme is very similar to those of other copper-containing nitrite reductases, folding as a trimer and containing two copper sites per monomer, the structures reported here enable conformational differences between the oxidized and reduced forms of the enzyme to be identified. In the type 1 copper site, a rotational perturbation of the side chain of the copper ligand Met182 occurs upon reduction. At the type 2 copper site, a dual conformation of the catalytic residue His287 is observed in the oxidized structure but is lacking in the reduced structure, such that the interactions of the oxidized type 2 copper ion can be regarded as adopting octahedral geometry. These findings shed light on the structural mechanism of the reduction of a copper-bound nitrite to nitric oxide and water.
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(as it appears on PubMed at http://www.pubmed.gov), where 16131751 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16131751}}
==About this Structure==
==About this Structure==
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[[Category: Denitrification]]
[[Category: Denitrification]]
[[Category: Nitrite reduction]]
[[Category: Nitrite reduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:06:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:56:50 2008''

Revision as of 14:56, 27 July 2008

Image:1zv2.png

Template:STRUCTURE 1zv2

Cu-containing nitrite reductase

Template:ABSTRACT PUBMED 16131751

About this Structure

1ZV2 is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Structures of the oxidized and reduced forms of nitrite reductase from Rhodobacter sphaeroides 2.4.3 at high pH: changes in the interactions of the type 2 copper., Jacobson F, Guo H, Olesen K, Okvist M, Neutze R, Sjolin L, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1190-8. Epub 2005, Aug 16. PMID:16131751

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