2j46

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{{STRUCTURE_2j46| PDB=2j46 | SCENE= }}
{{STRUCTURE_2j46| PDB=2j46 | SCENE= }}
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'''WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION'''
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===WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION===
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==Overview==
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Two new structures of the SRP GTPase Ffh have been determined at 1.1 A resolution and provide the basis for comparative examination of the extensive water structure of the apo conformation of these GTPases. A set of well defined water-binding positions have been identified in the active site of the two-domain ;NG' GTPase, as well as at two functionally important interfaces. The water hydrogen-bonding network accommodates alternate conformations of the protein side chains by undergoing local rearrangements and, in one case, illustrates binding of a solute molecule within the active site by displacement of water molecules without further disruption of the water-interaction network. A subset of the water positions are well defined in several lower resolution structures, including those of different nucleotide-binding states; these appear to function in maintaining the protein structure. Consistent arrangements of surface water between three different ultrahigh-resolution structures provide a framework for beginning to understand how local water structure contributes to protein-ligand and protein-protein binding in the SRP GTPases.
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(as it appears on PubMed at http://www.pubmed.gov), where 17139088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17139088}}
==About this Structure==
==About this Structure==
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[[Category: Srp]]
[[Category: Srp]]
[[Category: Water]]
[[Category: Water]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:00:48 2008''

Revision as of 15:00, 27 July 2008

Image:2j46.png

Template:STRUCTURE 2j46

WATER STRUCTURE OF T. AQUATICUS FFH NG DOMAIN AT 1.1A RESOLUTION

Template:ABSTRACT PUBMED 17139088

About this Structure

2J46 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh., Ramirez UD, Freymann DM, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34. Epub 2006, Nov 23. PMID:17139088

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