1s23

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{{STRUCTURE_1s23| PDB=1s23 | SCENE= }}
{{STRUCTURE_1s23| PDB=1s23 | SCENE= }}
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'''Crystal Structure Analysis of the B-DNA Decamer CGCAATTGCG'''
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===Crystal Structure Analysis of the B-DNA Decamer CGCAATTGCG===
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==Overview==
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The deoxyoligonucleotide d(CGCAATTGCG) has previously been crystallized in four different space groups. The crystals diffract to moderate resolution (2.3-2.9 A). Here, a fifth crystal form that diffracts to higher resolution (1.6 A) is presented which was obtained thanks to the use of Co2+ and cryogenic temperatures. The availability of five different crystal structures allows a thorough analysis of the conformational variability of this DNA sequence. It is concluded that the central hexamer sequence CAATTG has a practically constant conformation under all conditions, whilst the terminal base pairs at both ends vary considerably as a result of differing interactions in the crystals. The new crystal structure presented here is stabilized by guanine-Co2+-guanine interactions and the formation of C1+ -G8.C3 triplexes between neighbouring duplexes. As a result of the higher resolution of the crystal structure, a more regular structure was obtained and a clear definition of the spine of hydration was observed which was not visible in the four previous structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_15039556}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15039556 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15039556}}
==About this Structure==
==About this Structure==
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[[Category: Deoxyoligonucleotide]]
[[Category: Deoxyoligonucleotide]]
[[Category: Variability]]
[[Category: Variability]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:12:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:01:12 2008''

Revision as of 15:01, 27 July 2008

Image:1s23.png

Template:STRUCTURE 1s23

Crystal Structure Analysis of the B-DNA Decamer CGCAATTGCG

Template:ABSTRACT PUBMED 15039556

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA variability in five crystal structures of d(CGCAATTGCG)., Valls N, Wright G, Steiner RA, Murshudov GN, Subirana JA, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):680-5. Epub 2004, Mar 23. PMID:15039556

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