1ukm

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[[Image:1ukm.gif|left|200px]]
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{{STRUCTURE_1ukm| PDB=1ukm | SCENE= }}
{{STRUCTURE_1ukm| PDB=1ukm | SCENE= }}
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'''Crystal structure of EMS16, an Antagonist of collagen receptor integrin alpha2beta1 (GPIa/IIa)'''
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===Crystal structure of EMS16, an Antagonist of collagen receptor integrin alpha2beta1 (GPIa/IIa)===
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==Overview==
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Snake venoms contain a number of hemostatically active C-type lectin-like proteins (CLPs), which affect the blood coagulation system, endothelial cells, and platelets. CLPs have broad similarities in structure and possess distinct biological functions. EMS16, a CLP from Echis multisquamatus venom, which is a potent and selective inhibitor of the collagen receptor, glycoprotein Ia/IIa (integrin alpha2beta1), has been used in the present study to examine structure-function relationships in venom CLPs by X-ray crystallography. The structure of EMS16, determined at a resolution of 1.9 A, revealed a heterodimer involved with domain swapping of the central loop as observed in the structures of other CLPs. A part of the glycan was observed and identified as N-acetyl-D-glucosamine (GlcNAc) in the electron density map at Asn21 of subunit B, an expected glycosylation site. EMS16 had a unique, positively charged electrostatic potential patch on the concave surface that may qualify as a site for interaction with the I-domain of the glycoprotein Ia/IIa.
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The line below this paragraph, {{ABSTRACT_PUBMED_14580195}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14580195 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14580195}}
==About this Structure==
==About this Structure==
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[[Category: C-type lectin]]
[[Category: C-type lectin]]
[[Category: Domain swapping]]
[[Category: Domain swapping]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:21:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:07:33 2008''

Revision as of 15:07, 27 July 2008

Image:1ukm.png

Template:STRUCTURE 1ukm

Crystal structure of EMS16, an Antagonist of collagen receptor integrin alpha2beta1 (GPIa/IIa)

Template:ABSTRACT PUBMED 14580195

About this Structure

1UKM is a Protein complex structure of sequences from Echis multisquamatus. Full crystallographic information is available from OCA.

Reference

Structural characterization of EMS16, an antagonist of collagen receptor (GPIa/IIa) from the venom of Echis multisquamatus., Horii K, Okuda D, Morita T, Mizuno H, Biochemistry. 2003 Nov 4;42(43):12497-502. PMID:14580195

Page seeded by OCA on Sun Jul 27 18:07:33 2008

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