2htw

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[[Image:2htw.gif|left|200px]]
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{{Seed}}
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[[Image:2htw.png|left|200px]]
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{{STRUCTURE_2htw| PDB=2htw | SCENE= }}
{{STRUCTURE_2htw| PDB=2htw | SCENE= }}
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'''N4 neuraminidase in complex with DANA'''
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===N4 neuraminidase in complex with DANA===
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==Overview==
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The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16915235}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16915235 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16915235}}
==About this Structure==
==About this Structure==
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[[Category: N4]]
[[Category: N4]]
[[Category: Neuraminidase]]
[[Category: Neuraminidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:42:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:08:15 2008''

Revision as of 15:08, 27 July 2008

Image:2htw.png

Template:STRUCTURE 2htw

N4 neuraminidase in complex with DANA

Template:ABSTRACT PUBMED 16915235

About this Structure

2HTW is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design., Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ, Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235

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