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1uos

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{{STRUCTURE_1uos| PDB=1uos | SCENE= }}
{{STRUCTURE_1uos| PDB=1uos | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN'''
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===THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN===
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==Overview==
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Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly.
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The line below this paragraph, {{ABSTRACT_PUBMED_14684891}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14684891 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14684891}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:09:04 2008''

Revision as of 15:09, 27 July 2008

Image:1uos.png

Template:STRUCTURE 1uos

THE CRYSTAL STRUCTURE OF THE SNAKE VENOM TOXIN CONVULXIN

Template:ABSTRACT PUBMED 14684891

About this Structure

1UOS is a Protein complex structure of sequences from Crotalus durissus terrificus. Full crystallographic information is available from OCA.

Reference

Structure of the snake-venom toxin convulxin., Batuwangala T, Leduc M, Gibbins JM, Bon C, Jones EY, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):46-53. Epub 2003, Dec 18. PMID:14684891

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