This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1otz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1otz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1otz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1otz| PDB=1otz | SCENE= }}
{{STRUCTURE_1otz| PDB=1otz | SCENE= }}
-
'''Crystal structure of the BAFF-BAFF-R complex (part I)'''
+
===Crystal structure of the BAFF-BAFF-R complex (part I)===
-
==Overview==
+
<!--
-
B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACI and BAFF-R. We have determined the crystal structure of the extracellular domain of BAFF-R bound to BAFF at a resolution of 3.3 A. The cysteine-rich domain (CRD) of the BAFF-R extracellular domain adopts a beta-hairpin structure and binds to the virus-like BAFF cage in a 1:1 molar ratio. The conserved DxL motif of BAFF-R is located on the tip of the beta-turn and is indispensable in the binding of BAFF. The crystal structure shows that a unique dimeric contact occurs between the BAFF-R monomers in the virus-like cage complex. The extracellular domain of TACI contains two CRDs, both of which contain the DxL motif. Modeling of TACI-BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus-like cage.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12715002}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12715002 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12715002}}
==About this Structure==
==About this Structure==
Line 23: Line 27:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cytokine]]
[[Category: Cytokine]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:16:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:09:13 2008''

Revision as of 15:09, 27 July 2008

Image:1otz.png

Template:STRUCTURE 1otz

Crystal structure of the BAFF-BAFF-R complex (part I)

Template:ABSTRACT PUBMED 12715002

About this Structure

1OTZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation., Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO, Nat Struct Biol. 2003 May;10(5):342-8. PMID:12715002

Page seeded by OCA on Sun Jul 27 18:09:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1otz"
Personal tools