1vpw

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[[Image:1vpw.gif|left|200px]]
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{{STRUCTURE_1vpw| PDB=1vpw | SCENE= }}
{{STRUCTURE_1vpw| PDB=1vpw | SCENE= }}
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'''STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA'''
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===STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA===
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==Overview==
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The crystal structure of the purine repressor mutant L54M bound to hypoxanthine and to the purF operator provides a stereochemical understanding of the high DNA affinity of this hinge helix mutant. Comparison of the PurR L54M-DNA complex to that of the wild type PurR-DNA complex reveals that these purine repressors bind and kink DNA similarly despite significant differences in their minor groove contacts and routes to interdigitation of the central C.G:G.C base pair step. Modeling studies, supported by genetic and biochemical data, show that the stereochemistry of the backbone atoms of the abutting hinge helices combined with the rigidity of the kinked base pair step constrain the interdigitating residue to leucine or methionine for the LacI/GalR family of transcription regulators.
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(as it appears on PubMed at http://www.pubmed.gov), where 9628480 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9628480}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding regulatory protein]]
[[Category: Dna-binding regulatory protein]]
[[Category: Minor groove bending]]
[[Category: Minor groove bending]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:46:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:10:45 2008''

Revision as of 15:10, 27 July 2008

Image:1vpw.png

Template:STRUCTURE 1vpw

STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA

Template:ABSTRACT PUBMED 9628480

About this Structure

1VPW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of PurR mutant L54M shows an alternative route to DNA kinking., Arvidson DN, Lu F, Faber C, Zalkin H, Brennan RG, Nat Struct Biol. 1998 Jun;5(6):436-41. PMID:9628480

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