2dcw

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{{STRUCTURE_2dcw| PDB=2dcw | SCENE= }}
{{STRUCTURE_2dcw| PDB=2dcw | SCENE= }}
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'''The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif'''
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===The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif===
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==Overview==
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Tachystatin B is an antimicrobial and a chitin-binding peptide isolated from the Japanese horseshoe crab (Tachypleus tridentatus) consisting of two isopeptides called tachystatin B1 and B2. We have determined their solution structures using NMR experiments and distance geometry calculations. The 20 best converged structures of tachystatin B1 and B2 exhibited root mean square deviations of 0.46 and 0.49 A, respectively, for the backbone atoms in Cys(4)-Arg(40). Both structures have identical conformations, and they contain a short antiparallel beta-sheet with an inhibitory cystine-knot (ICK) motif that is distributed widely in the antagonists for voltage-gated ion channels, although tachystatin B does not have neurotoxic activity. The structural homology search provided several peptides with structures similar to that of tachystatin B. However, most of them have the advanced functions such as insecticidal activity, suggesting that tachystatin B may be a kind of ancestor of antimicrobial peptide in the molecular evolutionary history. Tachystatin B also displays a significant structural similarity to tachystatin A, which is member of the tachystatin family. The structural comparison of both tachystatins indicated that Tyr(14) and Arg(17) in the long loop between the first and second strands might be the essential residues for binding to chitin.
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(as it appears on PubMed at http://www.pubmed.gov), where 17394123 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17394123}}
==About this Structure==
==About this Structure==
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2DCW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCW OCA].
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2DCW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCW OCA].
==Reference==
==Reference==
The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif., Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K, J Pept Sci. 2007 Apr;13(4):269-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17394123 17394123]
The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif., Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K, J Pept Sci. 2007 Apr;13(4):269-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17394123 17394123]
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Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins., Osaki T, Omotezako M, Nagayama R, Hirata M, Iwanaga S, Kasahara J, Hattori J, Ito I, Sugiyama H, Kawabata S, J Biol Chem. 1999 Sep 10;274(37):26172-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10473569 10473569]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tachypleus tridentatus]]
[[Category: Tachypleus tridentatus]]
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[[Category: Antimicrobial]]
[[Category: Antimicrobial]]
[[Category: Cystine-knot]]
[[Category: Cystine-knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:11:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:11:47 2008''

Revision as of 15:11, 27 July 2008

Image:2dcw.png

Template:STRUCTURE 2dcw

The solution structure of horseshoe crab antimicrobial peptide tachystatin b with the inhibitory cystine-knot motif

Template:ABSTRACT PUBMED 17394123

About this Structure

2DCW is a Single protein structure of sequence from Tachypleus tridentatus. Full experimental information is available from OCA.

Reference

The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif., Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K, J Pept Sci. 2007 Apr;13(4):269-79. PMID:17394123

Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins., Osaki T, Omotezako M, Nagayama R, Hirata M, Iwanaga S, Kasahara J, Hattori J, Ito I, Sugiyama H, Kawabata S, J Biol Chem. 1999 Sep 10;274(37):26172-8. PMID:10473569

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