1wr0

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{{STRUCTURE_1wr0| PDB=1wr0 | SCENE= }}
{{STRUCTURE_1wr0| PDB=1wr0 | SCENE= }}
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'''Structural characterization of the MIT domain from human Vps4b'''
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===Structural characterization of the MIT domain from human Vps4b===
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==Overview==
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The microtubule interacting and trafficking (MIT) domain is a small protein module of unknown function that is conserved in proteins of diverse function, such as Vps4, sorting nexin 15 (SNX15), and spastin. One non-synonymous single nucleotide polymorphism was reported, which results in a Ile58-to-Met (I58M) substitution in hVps4b. Here, we have determined the solution structure of the MIT domain isolated from the NH(2)-terminus of human Vps4b, an AAA-ATPase involved in multivesicular body formation. The MIT domain adopts an 'up-and-down' three-helix bundle. Comparison with the sequences of other MIT domains clearly shows that the residues involved in inter-helical contacts are well conserved. The Ile58-to-Met substitution resulted a substantial thermal instability. In addition, we found a shallow crevice between helices A and C that may serve as a protein-binding site. We propose that the MIT domain serves as a putative adaptor domain for the ESCRT-III complex involved in endosomal trafficking.
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{{ABSTRACT_PUBMED_16018968}}
==About this Structure==
==About this Structure==
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1WR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR0 OCA].
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1WR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR0 OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Vps4b]]
[[Category: Vps4b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:02:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:12:00 2008''

Revision as of 15:12, 27 July 2008

Image:1wr0.png

Template:STRUCTURE 1wr0

Structural characterization of the MIT domain from human Vps4b

Template:ABSTRACT PUBMED 16018968

About this Structure

1WR0 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural characterization of the MIT domain from human Vps4b., Takasu H, Jee JG, Ohno A, Goda N, Fujiwara K, Tochio H, Shirakawa M, Hiroaki H, Biochem Biophys Res Commun. 2005 Aug 26;334(2):460-5. PMID:16018968

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