2o05

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{{STRUCTURE_2o05| PDB=2o05 | SCENE= }}
{{STRUCTURE_2o05| PDB=2o05 | SCENE= }}
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'''Human spermidine synthase'''
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===Human spermidine synthase===
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==Overview==
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Aminopropyltransferases transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines. Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for putrescine as the amine acceptor, and the Thermotoga maritima spermidine synthase, which prefers putrescine but is more tolerant of other substrates. Comparison of the structures of the human spermidine synthase with both substrates and products with the known structure of T. maritima spermidine synthase complexed to a multisubstrate analogue inhibitor and analysis of the properties of site-directed mutants provide a general mechanistic hypothesis for the aminopropyl transfer reaction. The studies also provide a structural basis for the specificity of the spermidine synthase subclass of the aminopropyltransferase family.
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{{ABSTRACT_PUBMED_17585781}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:08:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:13:07 2008''

Revision as of 15:13, 27 July 2008

Image:2o05.png

Template:STRUCTURE 2o05

Human spermidine synthase

Template:ABSTRACT PUBMED 17585781

About this Structure

2O05 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1zdz. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of spermidine synthases., Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN, Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22. PMID:17585781

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