2hbh

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{{STRUCTURE_2hbh| PDB=2hbh | SCENE= }}
{{STRUCTURE_2hbh| PDB=2hbh | SCENE= }}
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'''Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide'''
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===Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide===
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==Overview==
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The crystal structures of vitamin D nuclear receptor (VDR) have revealed that all compounds are anchored by the same residues to the ligand binding pocket (LBP). Based on this observation, a synthetic analog with a locked side chain (21-nor-calcitriol-20(22),23-diyne) has been synthesized in order to gain in entropy energy with a predefined active side chain conformation. The crystal structure of VDR LBD bound to this locked side chain analogue while confirming the docking provides a structural basis for the activity of this compound.
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(as it appears on PubMed at http://www.pubmed.gov), where 17346665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17346665}}
==About this Structure==
==About this Structure==
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[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
[[Category: Alpha helical sandwich]]
[[Category: Alpha helical sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:05:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:14:41 2008''

Revision as of 15:14, 27 July 2008

Image:2hbh.png

Template:STRUCTURE 2hbh

Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide

Template:ABSTRACT PUBMED 17346665

About this Structure

2HBH is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

Reference

Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol., Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mourino A, Moras D, Arch Biochem Biophys. 2007 Apr 15;460(2):172-6. Epub 2007 Feb 20. PMID:17346665

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