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1r54

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{{STRUCTURE_1r54| PDB=1r54 | SCENE= }}
{{STRUCTURE_1r54| PDB=1r54 | SCENE= }}
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'''Crystal structure of the catalytic domain of human ADAM33'''
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===Crystal structure of the catalytic domain of human ADAM33===
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==Overview==
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Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 14659745 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14659745}}
==About this Structure==
==About this Structure==
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[[Category: Asthma]]
[[Category: Asthma]]
[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:15:10 2008''

Revision as of 15:15, 27 July 2008

Image:1r54.png

Template:STRUCTURE 1r54

Crystal structure of the catalytic domain of human ADAM33

Template:ABSTRACT PUBMED 14659745

About this Structure

1R54 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745

Page seeded by OCA on Sun Jul 27 18:15:10 2008

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