3c59

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{{STRUCTURE_3c59| PDB=3c59 | SCENE= }}
{{STRUCTURE_3c59| PDB=3c59 | SCENE= }}
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'''Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain'''
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===Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain===
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==Overview==
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The glucagon-like peptide-1 receptor (GLP-1R) belongs to Family B1 of the seven-transmembrane G protein-coupled receptors, and its natural agonist ligand is the peptide hormone glucagon-like peptide-1 (GLP-1). GLP-1 is involved in glucose homeostasis, and activation of GLP-1R in the plasma membrane of pancreatic beta-cells potentiates glucose-dependent insulin secretion. The N-terminal extracellular domain (nGLP-1R) is an important ligand binding domain that binds GLP-1 and the homologous peptide Exendin-4 with differential affinity. Exendin-4 has a C-terminal extension of nine amino acid residues known as the "Trp cage", which is absent in GLP-1. The Trp cage was believed to interact with nGLP-1R and thereby explain the superior affinity of Exendin-4. However, the molecular details that govern ligand binding and specificity of nGLP-1R remain undefined. Here we report the crystal structure of human nGLP-1R in complex with the antagonist Exendin-4(9-39) solved by the multiwavelength anomalous dispersion method to 2.2A resolution. The structure reveals that Exendin-4(9-39) is an amphipathic alpha-helix forming both hydrophobic and hydrophilic interactions with nGLP-1R. The Trp cage of Exendin-4 is not involved in binding to nGLP-1R. The hydrophobic binding site of nGLP-1R is defined by discontinuous segments including primarily a well defined alpha-helix in the N terminus of nGLP-1R and a loop between two antiparallel beta-strands. The structure provides for the first time detailed molecular insight into ligand binding of the human GLP-1 receptor, an established target for treatment of type 2 diabetes.
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{{ABSTRACT_PUBMED_18287102}}
==About this Structure==
==About this Structure==
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[[Category: Transducer]]
[[Category: Transducer]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:16:30 2008''

Revision as of 15:16, 27 July 2008

Image:3c59.png


PDB ID 3c59

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3c59, resolution 2.30Å ()
Sites:
Ligands:
Non-Standard Residues:
Gene: Glucagon-like peptide-1 receptor(GLP1R) (Homo sapiens)
Related: 3c5t
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Template:ABSTRACT PUBMED 18287102

About this Structure

3C59 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain., Runge S, Thogersen H, Madsen K, Lau J, Rudolph R, J Biol Chem. 2008 Apr 25;283(17):11340-7. Epub 2008 Feb 20. PMID:18287102

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