2int

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[[Image:2int.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2int| PDB=2int | SCENE= }}
{{STRUCTURE_2int| PDB=2int | SCENE= }}
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4'''
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===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4===
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==Overview==
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The crystal structure of recombinant human interleukin-4 (rhuIL-4) was initially determined at 3.5-A resolution by multiple isomorphous replacement techniques and subsequently refined to a resolution of 2.35 A by simulated annealing. The final crystallographic R-factor, based on all data in the range 6.0-2.35 A (7470 reflections), is 0.232. Bond lengths and bond angles in the molecule have root mean square deviations from ideal values of 0.016 A and 2.4 degrees, respectively. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhuIL-4 is a four alpha-helix bundle, which composes approximately 58% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within these connections is a two-stranded antiparallel beta-sheet. Both the tertiary and secondary structures of rhuIL-4 are similar to those of human granulocyte-macrophage colony-stimulating factor. Critical regions for receptor binding are proposed.
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The line below this paragraph, {{ABSTRACT_PUBMED_1400355}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1400355 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1400355}}
==About this Structure==
==About this Structure==
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[[Category: Zhao, B G.]]
[[Category: Zhao, B G.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:41:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:18:01 2008''

Revision as of 15:18, 27 July 2008

Image:2int.png

Template:STRUCTURE 2int

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4

Template:ABSTRACT PUBMED 1400355

About this Structure

2INT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human interleukin-4., Walter MR, Cook WJ, Zhao BG, Cameron RP Jr, Ealick SE, Walter RL Jr, Reichert P, Nagabhushan TL, Trotta PP, Bugg CE, J Biol Chem. 1992 Oct 5;267(28):20371-6. PMID:1400355

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