1tdp

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{{STRUCTURE_1tdp| PDB=1tdp | SCENE= }}
{{STRUCTURE_1tdp| PDB=1tdp | SCENE= }}
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'''NMR solution structure of the carnobacteriocin B2 immunity protein'''
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===NMR solution structure of the carnobacteriocin B2 immunity protein===
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==Overview==
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Bacteriocins produced by lactic acid bacteria are potent antimicrobial compounds which are active against closely related bacteria. Producer strains are protected against the effects of their cognate bacteriocins by immunity proteins that are located on the same genetic locus and are coexpressed with the gene encoding the bacteriocin. Several structures are available for class IIa bacteriocins; however, to date, no structures are available for the corresponding immunity proteins. We report here the NMR solution structure of the 111-amino acid immunity protein for carnobacteriocin B2 (ImB2). ImB2 folds into a globular domain in aqueous solution which contains an antiparallel four-helix bundle. Extensive packing by hydrophobic side chains in adjacent helices forms the core of the protein. The C-terminus, containing a fifth helix and an extended strand, is held against the four-helix bundle by hydrophobic interactions with helices 3 and 4. Most of the charged and polar residues in the protein face the solvent. Helix 3 is well-defined to residue 55, and a stretch of nascent helix followed by an unstructured loop joins it to helix 4. No interaction is observed between ImB2 and either carnobacteriocin B2 (CbnB2) or its precursor. Protection from the action of CbnB2 is only observed when ImB2 is expressed within the cell. The loop between helices 3 and 4, and a hydrophobic pocket which it partially masks, may be important for interaction with membrane receptors responsible for sensitivity to class IIa bacteriocins.
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{{ABSTRACT_PUBMED_15362858}}
==About this Structure==
==About this Structure==
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1TDP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Carnobacterium_maltaromaticum Carnobacterium maltaromaticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDP OCA].
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1TDP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Carnobacterium_maltaromaticum Carnobacterium maltaromaticum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDP OCA].
==Reference==
==Reference==
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[[Category: Vederas, J C.]]
[[Category: Vederas, J C.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:19:58 2008''

Revision as of 15:20, 27 July 2008

Image:1tdp.png

Template:STRUCTURE 1tdp

NMR solution structure of the carnobacteriocin B2 immunity protein

Template:ABSTRACT PUBMED 15362858

About this Structure

1TDP is a Single protein structure of sequence from Carnobacterium maltaromaticum. Full experimental information is available from OCA.

Reference

NMR solution structure of ImB2, a protein conferring immunity to antimicrobial activity of the type IIa bacteriocin, carnobacteriocin B2., Sprules T, Kawulka KE, Vederas JC, Biochemistry. 2004 Sep 21;43(37):11740-9. PMID:15362858

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