2i91

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[[Image:2i91.gif|left|200px]]
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{{Seed}}
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[[Image:2i91.png|left|200px]]
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{{STRUCTURE_2i91| PDB=2i91 | SCENE= }}
{{STRUCTURE_2i91| PDB=2i91 | SCENE= }}
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'''60kDa Ro autoantigen in complex with a fragment of misfolded RNA'''
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===60kDa Ro autoantigen in complex with a fragment of misfolded RNA===
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==Overview==
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The Ro autoantigen is ring-shaped, binds misfolded noncoding RNAs and is proposed to function in quality control. Here we determine how Ro interacts with misfolded RNAs. Binding of Ro to misfolded precursor (pre)-5S ribosomal RNA requires a single-stranded 3' end and helical elements. As mutating most sequences of the helices and tail results in modest decreases in binding, Ro may be able to associate with a range of RNAs. Ro binds several other RNAs that contain single-stranded tails. A crystal structure of Ro bound to a misfolded pre-5S rRNA fragment reveals that the tail inserts into the cavity, while a helix binds on the surface. Most contacts of Ro with the helix are to the backbone. Mutagenesis reveals that Ro has an extensive RNA-binding surface. We propose that Ro uses this surface to scavenge RNAs that fail to bind their specific RNA-binding proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17041599 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17041599}}
==About this Structure==
==About this Structure==
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[[Category: Rossmann-fold]]
[[Category: Rossmann-fold]]
[[Category: Von willebrand factor some]]
[[Category: Von willebrand factor some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:12:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:20:42 2008''

Revision as of 15:20, 27 July 2008

Image:2i91.png

Template:STRUCTURE 2i91

60kDa Ro autoantigen in complex with a fragment of misfolded RNA

Template:ABSTRACT PUBMED 17041599

About this Structure

2I91 is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen., Fuchs G, Stein AJ, Fu C, Reinisch KM, Wolin SL, Nat Struct Mol Biol. 2006 Nov;13(11):1002-9. Epub 2006 Oct 15. PMID:17041599

Page seeded by OCA on Sun Jul 27 18:20:42 2008

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