1u8c

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[[Image:1u8c.jpg|left|200px]]
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{{STRUCTURE_1u8c| PDB=1u8c | SCENE= }}
{{STRUCTURE_1u8c| PDB=1u8c | SCENE= }}
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'''A novel adaptation of the integrin PSI domain revealed from its crystal structure'''
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===A novel adaptation of the integrin PSI domain revealed from its crystal structure===
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==Overview==
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Integrin beta-subunits contain an N-terminal PSI (for plexin-semaphorin-integrin) domain that contributes to integrin activation and harbors the PI(A) alloantigen associated with immune thrombocytopenias and susceptibility to sudden cardiac death. Here we report the crystal structure of PSI in the context of the crystallized alphaVbeta3 ectodomain. The integrin PSI forms a two-stranded antiparallel beta-sheet flanked by two short helices; its long interstrand loop houses Pl(A) and may face the EGF2 domain. The integrin PSI contains four cysteine pairs connected in a 1-4, 2-8, 3-6, 5-7 pattern. An unexpected feature of the structure is that the final, eighth cysteine is located C-terminal to the Ig-like hybrid domain and is thus separated by the hybrid domain from the other seven cysteines of PSI. This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15299032}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15299032 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299032}}
==About this Structure==
==About this Structure==
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[[Category: Psi domain]]
[[Category: Psi domain]]
[[Category: Vitronectrin receptor]]
[[Category: Vitronectrin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:23:27 2008''

Revision as of 15:23, 27 July 2008

Image:1u8c.png

Template:STRUCTURE 1u8c

A novel adaptation of the integrin PSI domain revealed from its crystal structure

Template:ABSTRACT PUBMED 15299032

About this Structure

1U8C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:15299032

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