2ihs

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{{STRUCTURE_2ihs| PDB=2ihs | SCENE= }}
{{STRUCTURE_2ihs| PDB=2ihs | SCENE= }}
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'''Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide'''
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===Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide===
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==Overview==
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B30.2/SPRY domains are found in numerous proteins that cover a wide spectrum of biological functions, including regulation of cytokine signaling and innate retroviral restriction. Herein, we report the crystal structure of the B30.2/SPRY domain of a SPRY domain-containing SOCS box (SSB) protein, GUSTAVUS, complexed with a 20 amino acid peptide derived from the RNA helicase VASA, revealing how these domains recognize target proteins. The peptide-binding site is conformationally rigid and has a preformed pocket. The interaction between the pocket and the Asp-Ile-Asn-Asn-Asn-Asn sequence within the peptide accounts for the high-affinity binding between GUSTAVUS and VASA. This observation led to a facile identification of the Glu-Leu-Asn-Asn-Asn-Leu sequence as the recognition motif in a proapoptotic protein Par-4 for its interaction with a GUSTAVUS homolog, SSB-1. Ensuing analyses indicated that many B30.2/SPRY domains have a similar preformed pocket, which would allow them to bind multiple targets.
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{{ABSTRACT_PUBMED_17189197}}
==About this Structure==
==About this Structure==
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[[Category: Trim family]]
[[Category: Trim family]]
[[Category: Vasa]]
[[Category: Vasa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:31:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:26:37 2008''

Revision as of 15:26, 27 July 2008

Image:2ihs.png

Template:STRUCTURE 2ihs

Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide

Template:ABSTRACT PUBMED 17189197

About this Structure

2IHS is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for protein recognition by B30.2/SPRY domains., Woo JS, Suh HY, Park SY, Oh BH, Mol Cell. 2006 Dec 28;24(6):967-76. PMID:17189197

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