1knc

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(New page: 200px<br /><applet load="1knc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1knc, resolution 2.00&Aring;" /> '''Structure of AhpD fr...)
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Revision as of 17:17, 20 November 2007

Image:1knc.gif

1knc, resolution 2.00Å

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Structure of AhpD from Mycobacterium tuberculosis, a novel enzyme with thioredoxin-like activity.

Overview

Mycobacterium tuberculosis (Mtb) mounts a stubborn defense against, oxidative and nitrosative components of the immune response., Dihydrolipoamide dehydrogenase (Lpd) and dihydrolipoamide, succinyltransferase (SucB) are components of alpha-ketoacid dehydrogenase, complexes that are central to intermediary metabolism. We find that Lpd, and SucB support Mtb's antioxidant defense. The peroxiredoxin alkyl, hydroperoxide reductase (AhpC) is linked to Lpd and SucB by an adaptor, protein, AhpD. The 2.0 angstrom AhpD crystal structure reveals a, thioredoxin-like active site that is responsive to lipoamide. We propose, that Lpd, SucB (the only lipoyl protein detected in Mtb), AhpD, and AhpC, together constitute a nicotinamide adenine dinucleotide, (reduced)-dependent peroxidase and peroxynitrite reductase. AhpD thus, represents a class of thioredoxin-like molecules that enables an, antioxidant defense.

About this Structure

1KNC is a Single protein structure of sequence from Mycobacterium tuberculosis with SO4 as ligand. Full crystallographic information is available from OCA.

Reference

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein., Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C, Science. 2002 Feb 8;295(5557):1073-7. Epub 2002 Jan 17. PMID:11799204

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