2j9i

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{{STRUCTURE_2j9i| PDB=2j9i | SCENE= }}
{{STRUCTURE_2j9i| PDB=2j9i | SCENE= }}
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'''LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.'''
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===LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.===
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==Overview==
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Lengsin is a major protein of the vertebrate eye lens. It belongs to the hitherto purely prokaryotic GS I branch of the glutamine synthetase (GS) superfamily, but has no enzyme activity. Like the taxon-specific crystallins, Lengsin is the result of the recruitment of an ancient enzyme to a noncatalytic role in the vertebrate lens. Cryo-EM and modeling studies of Lengsin show a dodecamer structure with important similarities and differences with prokaryotic GS I structures. GS homology regions of Lengsin are well conserved, but the N-terminal domain shows evidence of dynamic evolutionary changes. Compared with birds and fish, most mammals have an additional exon corresponding to part of the N-terminal domain; however, in human, this is a nonfunctional pseudoexon. Genes related to Lengsin are also present in the sea urchin, suggesting that this branch of the GS I family, supplanted by GS II enzymes in vertebrates, has an ancient role in metazoans.
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(as it appears on PubMed at http://www.pubmed.gov), where 17161372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17161372}}
==About this Structure==
==About this Structure==
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[[Category: Wyatt, K.]]
[[Category: Wyatt, K.]]
[[Category: Ligase]]
[[Category: Ligase]]
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Revision as of 15:32, 27 July 2008

Image:2j9i.png

Template:STRUCTURE 2j9i

LENGSIN IS A SURVIVOR OF AN ANCIENT FAMILY OF CLASS I GLUTAMINE SYNTHETASES IN EUKARYOTES THAT HAS UNDERGONE EVOLUTIONARY RE-ENGINEERING FOR A TISSUE-SPECIFIC ROLE IN THE VERTEBRATE EYE LENS.

Template:ABSTRACT PUBMED 17161372

About this Structure

2J9I is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens., Wyatt K, White HE, Wang L, Bateman OA, Slingsby C, Orlova EV, Wistow G, Structure. 2006 Dec;14(12):1823-34. PMID:17161372

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