2jq2

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{{STRUCTURE_2jq2| PDB=2jq2 | SCENE= }}
{{STRUCTURE_2jq2| PDB=2jq2 | SCENE= }}
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'''NMR structure of the anticoccidial peptide PW2 in DPC micelles'''
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===NMR structure of the anticoccidial peptide PW2 in DPC micelles===
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==Overview==
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PW2 is an anticoccidial peptide active against Eimeria acervulina and Eimeria tenella. We determined the structure of PW2 in dodecylphosphocholine micelles. The structure showed two distinct regions: an amphipathic N-terminal 3(10) helix and an aromatic region containing WWR interface-binding motif. The aromatic region acted as a scaffold of the protein in the interface and shared the same structure in both DPC and SDS micelles. N-terminal helix interacted with DPC but not with SDS interface. Chemical shift change was slow when SDS was added to PW2 in DPC and fast when DPC was added to PW2 in SDS, indicating that interaction with DPC micelles was kinetically more stable than with SDS micelles. Also, DPC interface was able to accommodate PW2, but it maintained the conformational arrangement in the aromatic region observed for SDS micelles. This behavior, which is different from that observed for other antimicrobial peptides with WWR motif, may be associated with the absence of PW2 antibacterial activity and its selectivity for Eimeria parasites.
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The line below this paragraph, {{ABSTRACT_PUBMED_17926009}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17926009 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17926009}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ2 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ2 OCA].
==Reference==
==Reference==
Effect of micelle interface on the binding of anticoccidial PW2 peptide., Tinoco LW, Gomes-Neto F, Valente AP, Almeida FC, J Biomol NMR. 2007 Dec;39(4):315-22. Epub 2007 Oct 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17926009 17926009]
Effect of micelle interface on the binding of anticoccidial PW2 peptide., Tinoco LW, Gomes-Neto F, Valente AP, Almeida FC, J Biomol NMR. 2007 Dec;39(4):315-22. Epub 2007 Oct 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17926009 17926009]
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NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries., Tinoco LW, Da Silva A Jr, Leite A, Valente AP, Almeida FC, J Biol Chem. 2002 Sep 27;277(39):36351-6. Epub 2002 Jul 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12130641 12130641]
[[Category: Almeida, F C.]]
[[Category: Almeida, F C.]]
[[Category: Gomes-Neto, F.]]
[[Category: Gomes-Neto, F.]]
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[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Pw2]]
[[Category: Pw2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:10:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:36:13 2008''

Revision as of 15:36, 27 July 2008

Image:2jq2.png

Template:STRUCTURE 2jq2

NMR structure of the anticoccidial peptide PW2 in DPC micelles

Template:ABSTRACT PUBMED 17926009

About this Structure

Full experimental information is available from OCA.

Reference

Effect of micelle interface on the binding of anticoccidial PW2 peptide., Tinoco LW, Gomes-Neto F, Valente AP, Almeida FC, J Biomol NMR. 2007 Dec;39(4):315-22. Epub 2007 Oct 10. PMID:17926009

NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries., Tinoco LW, Da Silva A Jr, Leite A, Valente AP, Almeida FC, J Biol Chem. 2002 Sep 27;277(39):36351-6. Epub 2002 Jul 18. PMID:12130641

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