1y54

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{{STRUCTURE_1y54| PDB=1y54 | SCENE= }}
{{STRUCTURE_1y54| PDB=1y54 | SCENE= }}
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'''Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715'''
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===Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715===
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==Overview==
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BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, is an active-site-directed inactivator of bacterial beta-lactamases. The crystal structure of Enterobacter cloacae 908R class C beta-lactamase in complex with BRL 42715, docking, and energy minimization studies explain stereoselectivity of the binding of C6-(heterocyclic methylene)penems against class C beta-lactamase.
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{{ABSTRACT_PUBMED_15755127}}
==About this Structure==
==About this Structure==
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[[Category: Wouters, J.]]
[[Category: Wouters, J.]]
[[Category: Class c beta-lactamase]]
[[Category: Class c beta-lactamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:53:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:36:54 2008''

Revision as of 15:36, 27 July 2008

Template:STRUCTURE 1y54

Crystal structure of the native class C beta-lactamase from Enterobacter cloacae 908R complexed with BRL42715

Template:ABSTRACT PUBMED 15755127

About this Structure

1Y54 is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of BRL 42715, C6-(N1-methyl-1,2,3-triazolylmethylene)penem, in complex with Enterobacter cloacae 908R beta-lactamase: evidence for a stereoselective mechanism from docking studies., Michaux C, Charlier P, Frere JM, Wouters J, J Am Chem Soc. 2005 Mar 16;127(10):3262-3. PMID:15755127

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