1qfa

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[[Image:1qfa.jpg|left|200px]]
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{{Seed}}
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[[Image:1qfa.png|left|200px]]
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{{STRUCTURE_1qfa| PDB=1qfa | SCENE= }}
{{STRUCTURE_1qfa| PDB=1qfa | SCENE= }}
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'''STRUCTURE OF A NEUROPEPTIDE Y Y2 AGONIST'''
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===STRUCTURE OF A NEUROPEPTIDE Y Y2 AGONIST===
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==Overview==
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The solution structure and self-association behaviour of a 13 residue peptide analogue of the C-terminal region of human neuropeptide Y (NPY) have been investigated. NMR analysis of Ac[Leu(28,31)]NPY(24-36), a potent Y2 receptor agonist, shows that it is unstructured in aqueous solution at 5-20 degrees C, but forms a well-defined helix (encompassing residues 25-35) in 40% trifluoroethanol/water at 20 degrees C. Sedimentation experiments show that, in contrast to many peptides in aqueous trifluoroethanol, Ac[Leu(28,31)]NPY(24-36) associates to form a trimer or, more likely, a tetramer in 40% trifluoroethanol, even though it is monomeric in water. This is consistent with the observation of inter-molecular nuclear Overhauser enhancements in trifluoroethanol. Possible models of the associated form that are consistent with the NMR data are described. The relevance of the helical structure observed in trifluoroethanol to the structure of this peptide bound to the NPY Y2 receptor is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_10561544}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10561544 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10561544}}
==About this Structure==
==About this Structure==
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1QFA is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFA OCA].
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1QFA is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFA OCA].
==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Neuropeptide y]]
[[Category: Neuropeptide y]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:37:21 2008''

Revision as of 15:37, 27 July 2008

Image:1qfa.png

Template:STRUCTURE 1qfa

STRUCTURE OF A NEUROPEPTIDE Y Y2 AGONIST

Template:ABSTRACT PUBMED 10561544

About this Structure

1QFA is a Single protein structure. Full experimental information is available from OCA.

Reference

Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity., Barnham KJ, Catalfamo F, Pallaghy PK, Howlett GJ, Norton RS, Biochim Biophys Acta. 1999 Nov 16;1435(1-2):127-37. PMID:10561544

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