3bzc

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{{STRUCTURE_3bzc| PDB=3bzc | SCENE= }}
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'''Crystal Structure of the Tex protein from Pseudomonas aeruginosa, crystal form I'''
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===Crystal Structure of the Tex protein from Pseudomonas aeruginosa, crystal form I===
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==Overview==
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Tex is a highly conserved bacterial protein that likely functions in a variety of transcriptional processes. Here, we describe two crystal structures of the 86-kDa Tex protein from Pseudomonas aeruginosa at 2.3 and 2.5 A resolution, respectively. These structures reveal a relatively flat and elongated protein, with several potential nucleic acid binding motifs clustered at one end, including an S1 domain near the C-terminus that displays considerable structural flexibility. Tex binds nucleic acids, with a preference for single-stranded RNA, and the Tex S1 domain is required for this binding activity. Point mutants further demonstrate that the primary nucleic acid binding site corresponds to a surface of the S1 domain. Sequence alignment and modeling indicate that the eukaryotic Spt6 transcription factor adopts a similar core structure. Structural analysis further suggests that the RNA polymerase and nucleosome interacting regions of Spt6 flank opposite sides of the Tex-like scaffold. Therefore, the Tex structure may represent a conserved scaffold that binds single-stranded RNA to regulate transcription in both eukaryotic and prokaryotic organisms.
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(as it appears on PubMed at http://www.pubmed.gov), where 18321528 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Yqgf domain]]
[[Category: Yqgf domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:42:32 2008''

Revision as of 15:42, 27 July 2008

Image:3bzc.png

Template:STRUCTURE 3bzc

Crystal Structure of the Tex protein from Pseudomonas aeruginosa, crystal form I

Template:ABSTRACT PUBMED 18321528

About this Structure

3BZC is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa., Johnson SJ, Close D, Robinson H, Vallet-Gely I, Dove SL, Hill CP, J Mol Biol. 2008 Apr 11;377(5):1460-73. Epub 2008 Feb 12. PMID:18321528

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