This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j8o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2j8o.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2j8o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2j8o| PDB=2j8o | SCENE= }}
{{STRUCTURE_2j8o| PDB=2j8o | SCENE= }}
-
'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169'''
+
===STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169===
-
==Overview==
+
<!--
-
Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains, A168 and A169, located within the A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational flexibility of tandem domain motifs in titin. An unusual bulge within the second domain, A169, is directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both the mechanical properties of titin and for sarcomeric signaling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17574571}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17574571 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17574571}}
==About this Structure==
==About this Structure==
Line 49: Line 53:
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Wd repeat]]
[[Category: Wd repeat]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:30:55 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:46:15 2008''

Revision as of 15:46, 27 July 2008

Image:2j8o.png

Template:STRUCTURE 2j8o

STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT OF TITIN A168-A169

Template:ABSTRACT PUBMED 17574571

About this Structure

2J8O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin., Muller S, Lange S, Gautel M, Wilmanns M, J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571

Page seeded by OCA on Sun Jul 27 18:46:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j8o"
Personal tools