1xtz

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[[Image:1xtz.gif|left|200px]]
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{{STRUCTURE_1xtz| PDB=1xtz | SCENE= }}
{{STRUCTURE_1xtz| PDB=1xtz | SCENE= }}
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'''Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archeal and bacterial enzymes'''
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===Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archeal and bacterial enzymes===
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==Overview==
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Ribose-5-phosphate isomerase A has an important role in sugar metabolism by interconverting ribose-5-phosphate and ribulose-5-phosphate. This enzyme is ubiquitous and highly conserved among the three kingdoms of life. We have solved the 2.1 A resolution crystal structure of the Saccharomyces cerevisiae enzyme by molecular replacement. This protein adopts the same fold as its archaeal and bacterial orthologs with two alpha/beta domains tightly packed together. Mapping of conserved residues at the surface of the protein reveals strong invariability of the active site pocket, suggesting a common ligand binding mode and a similar catalytic mechanism. The yeast enzyme associates as a homotetramer similarly to the archaeal protein. The effect of an inactivating mutation (Arg189 to Lys) is discussed in view of the information brought by this structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_16054529}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16054529 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16054529}}
==About this Structure==
==About this Structure==
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[[Category: D-ribose-5-phosphate isomerase]]
[[Category: D-ribose-5-phosphate isomerase]]
[[Category: Yeast]]
[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:30:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:47:34 2008''

Revision as of 15:47, 27 July 2008

Image:1xtz.png

Template:STRUCTURE 1xtz

Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archeal and bacterial enzymes

Template:ABSTRACT PUBMED 16054529

About this Structure

1XTZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase: comparison with the archaeal and bacterial enzymes., Graille M, Meyer P, Leulliot N, Sorel I, Janin J, Van Tilbeurgh H, Quevillon-Cheruel S, Biochimie. 2005 Aug;87(8):763-9. Epub 2005 Apr 5. PMID:16054529

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