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2ot8

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[[Image:2ot8.gif|left|200px]]
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{{Seed}}
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[[Image:2ot8.png|left|200px]]
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{{STRUCTURE_2ot8| PDB=2ot8 | SCENE= }}
{{STRUCTURE_2ot8| PDB=2ot8 | SCENE= }}
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'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
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===Karyopherin Beta2/Transportin-hnRNPM NLS Complex===
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==Overview==
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Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.
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(as it appears on PubMed at http://www.pubmed.gov), where 17435768 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17435768}}
==About this Structure==
==About this Structure==
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[[Category: Karyopherin]]
[[Category: Karyopherin]]
[[Category: Nuclear import complex]]
[[Category: Nuclear import complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:36:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:48:12 2008''

Revision as of 15:48, 27 July 2008

Image:2ot8.png

Template:STRUCTURE 2ot8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex

Template:ABSTRACT PUBMED 17435768

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768

Page seeded by OCA on Sun Jul 27 18:48:12 2008

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