This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3bct
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="3bct" size="450" color="white" frame="true" align="right" spinBox="true" caption="3bct, resolution 2.10Å" /> '''THE ARMADILLO REPEAT...)
Next diff →
Revision as of 17:19, 20 November 2007
|
THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN
Overview
Beta-catenin is essential for cadherin-based cell adhesion and, Wnt/Wingless growth factor signaling. In these roles, it binds to, cadherins, Tcf-family transcription factors, and the tumor suppressor gene, product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an, armadillo repeat, mediates these interactions. The three-dimensional, structure of a protease-resistant fragment of beta-catenin containing the, armadillo repeat region has been determined. The 12 repeats form a, superhelix of helices that features a long, positively charged groove., Although unrelated in sequence, the beta-catenin binding regions of, cadherins, Tcfs, and APC are acidic and are proposed to interact with this, groove.
About this Structure
3BCT is a Single protein structure of sequence from Mus musculus with CL and URE as ligands. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899
Page seeded by OCA on Tue Nov 20 19:26:45 2007
Categories: Mus musculus | Single protein | Huber, A.H. | Nelson, W.J. | Weis, W.I. | CL | URE | Armadillo repeat | Beta-catenin | Cytoskeleton
