1y0q

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{{STRUCTURE_1y0q| PDB=1y0q | SCENE= }}
{{STRUCTURE_1y0q| PDB=1y0q | SCENE= }}
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'''Crystal structure of an active group I ribozyme-product complex'''
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===Crystal structure of an active group I ribozyme-product complex===
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==Overview==
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Group I introns are catalytic RNAs capable of orchestrating two sequential phosphotransesterification reactions that result in self-splicing. To understand how the group I intron active site facilitates catalysis, we have solved the structure of an active ribozyme derived from the orf142-I2 intron from phage Twort bound to a four-nucleotide product RNA at a resolution of 3.6 A. In addition to the three conserved domains characteristic of all group I introns, the Twort ribozyme has peripheral insertions characteristic of phage introns. These elements form a ring that completely envelops the active site, where a snug pocket for guanosine is formed by a series of stacked base triples. The structure of the active site reveals three potential binding sites for catalytic metals, and invokes a role for the 2' hydroxyl of the guanosine substrate in organization of the active site for catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 15580277 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15580277}}
==About this Structure==
==About this Structure==
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[[Category: Rna-folding]]
[[Category: Rna-folding]]
[[Category: Rna-splicing]]
[[Category: Rna-splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:44:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:51:56 2008''

Revision as of 15:51, 27 July 2008

Image:1y0q.png

Template:STRUCTURE 1y0q

Crystal structure of an active group I ribozyme-product complex

Template:ABSTRACT PUBMED 15580277

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a phage Twort group I ribozyme-product complex., Golden BL, Kim H, Chase E, Nat Struct Mol Biol. 2005 Jan;12(1):82-9. Epub 2004 Dec 5. PMID:15580277

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