1nuk

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[[Image:1nuk.gif|left|200px]]
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{{STRUCTURE_1nuk| PDB=1nuk | SCENE= }}
{{STRUCTURE_1nuk| PDB=1nuk | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE'''
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===CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE===
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==Overview==
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The Eph receptors, which bind a group of cell-membrane-anchored ligands known as ephrins, represent the largest subfamily of receptor tyrosine kinases (RTKs). They are predominantly expressed in the developing and adult nervous system and are important in contact-mediated axon guidance, axon fasciculation and cell migration. Eph receptors are unique among other RTKs in that they fall into two subclasses with distinct ligand specificities, and in that they can themselves function as ligands to activate bidirectional cell-cell signalling. We report here the crystal structure at 2.9 A resolution of the amino-terminal ligand-binding domain of the EphB2 receptor (also known as Nuk). The domain folds into a compact jellyroll beta-sandwich composed of 11 antiparallel beta-strands. Using structure-based mutagenesis, we have identified an extended loop that is important for ligand binding and class specificity. This loop, which is conserved within but not between Eph RTK subclasses, packs against the concave beta-sandwich surface near positions at which missense mutations cause signalling defects, localizing the ligand-binding region on the surface of the receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 9853759 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9853759}}
==About this Structure==
==About this Structure==
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[[Category: Eph receptor tyrosine kinase]]
[[Category: Eph receptor tyrosine kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:59:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:52:02 2008''

Revision as of 15:52, 27 July 2008

Image:1nuk.png

Template:STRUCTURE 1nuk

CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE

Template:ABSTRACT PUBMED 9853759

About this Structure

1NUK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2., Himanen JP, Henkemeyer M, Nikolov DB, Nature. 1998 Dec 3;396(6710):486-91. PMID:9853759

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