2aab

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2aab.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2aab.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2aab| PDB=2aab | SCENE= }}
{{STRUCTURE_2aab| PDB=2aab | SCENE= }}
-
'''Structural basis of antigen mimicry in a clinically relevant melanoma antigen system'''
+
===Structural basis of antigen mimicry in a clinically relevant melanoma antigen system===
-
==Overview==
+
<!--
-
Although mimics of human tumor antigens are effective immunogens to overcome host unresponsiveness to the nominal antigen, the structural basis of this mimicry remains poorly defined. Therefore, in this study we have characterized the structural basis of the human high molecular weight-melanoma-associated antigen (HMW-MAA) mimicry by the mouse anti-idiotypic (anti-id) monoclonal antibody (mAb) MK2-23. Using x-ray crystallography, we have characterized the three-dimensional structure of the anti-id mAb MK2-23 Fab' and shown that its heavy chain complementarity-determining region (CDR3) (H3) and its light chain CDR1 (L1) are closely associated. These moieties are the source of HMW-MAA mimicry, since they display partial amino acid sequence homology along with a similar structural fold with the HMW-MAA core protein. Furthermore, a 15-residue peptide comprising the H3 loop of anti-id mAb MK2-23 demonstrates HMW-MAA-like in vitro and in vivo reactivity. This peptide in conjunction with the structural data will facilitate the characterization of the effect of the degree of antigen mimicry on the induction of a self-antigen-specific immune response by a mimic.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16227204}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16227204 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16227204}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Melanoma]]
[[Category: Melanoma]]
[[Category: Molecular mimicry]]
[[Category: Molecular mimicry]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:48:35 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:56:56 2008''

Revision as of 15:56, 27 July 2008

Image:2aab.png

Template:STRUCTURE 2aab

Structural basis of antigen mimicry in a clinically relevant melanoma antigen system

Template:ABSTRACT PUBMED 16227204

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of antigen mimicry in a clinically relevant melanoma antigen system., Chang CC, Hernandez-Guzman FG, Luo W, Wang X, Ferrone S, Ghosh D, J Biol Chem. 2005 Dec 16;280(50):41546-52. Epub 2005 Oct 14. PMID:16227204

Page seeded by OCA on Sun Jul 27 18:56:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2aab"
Personal tools