1yy3

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[[Image:1yy3.gif|left|200px]]
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{{STRUCTURE_1yy3| PDB=1yy3 | SCENE= }}
{{STRUCTURE_1yy3| PDB=1yy3 | SCENE= }}
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'''Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)'''
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===Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)===
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==Overview==
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The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine. It is unprecedented in nature as it uses the cofactor S-adenosylmethionine as the donor of a ribosyl group. We have determined the crystal structure of Bacillus subtilis QueA at a resolution of 2.9A. The structure reveals two domains representing a 6-stranded beta-barrel and an alpha beta alpha-sandwich, respectively. All amino acid residues invariant in the QueA enzymes of known sequence cluster at the interface of the two domains indicating the localization of the substrate binding region and active center. Comparison of the B. subtilis QueA structure with the structure of QueA from Thermotoga maritima suggests a high domain flexibility of this enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 17083917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17083917}}
==About this Structure==
==About this Structure==
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[[Category: S-adenosylmethionine:trna ribosyltransferase-isomerase]]
[[Category: S-adenosylmethionine:trna ribosyltransferase-isomerase]]
[[Category: Trna-modification]]
[[Category: Trna-modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:56:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:58:47 2008''

Revision as of 15:58, 27 July 2008

Image:1yy3.png

Template:STRUCTURE 1yy3

Structure of S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA)

Template:ABSTRACT PUBMED 17083917

About this Structure

1YY3 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase., Grimm C, Ficner R, Sgraja T, Haebel P, Klebe G, Reuter K, Biochem Biophys Res Commun. 2006 Dec 22;351(3):695-701. Epub 2006 Oct 30. PMID:17083917

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